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J Med Food. 2018 Nov;21(11):1106-1112. doi: 10.1089/jmf.2017.0141. Epub 2018 May 30.

Vaccinium Extracts as Modulators in Experimental Type 1 Diabetes.

Author information

1
1 Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy Târgu Mureş , Târgu Mureş, Romania .
2
2 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy Târgu Mureş , Târgu Mureş, Romania .
3
3 Department of Analytical Chemistry and Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy Târgu Mureş , Târgu Mureş, Romania .
4
4 Immunology Laboratory, Center for Advanced Medical and Pharmaceutical Research, University of Medicine and Pharmacy Târgu Mureş , Târgu Mureş, Romania .
5
5 Department of Toxicology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy Târgu Mureş , Târgu Mureş, Romania .
6
6 Department of Ophthalmology, Topmed Medical Center , Târgu Mureş, Romania .

Abstract

Antihyperglycemic effects of four extracts obtained from leaves and fruits of Vaccinium myrtillus and Vaccinium corymbosum were assessed in diabetic rats. In addition, the effects of extracts on diabetic-related complications such as the development of diabetic cataract and oxidative stress were evaluated. Type 1 diabetes was induced with a single dose of streptozotocin in Wistar rats. The rats were randomly divided into seven equal groups: NC-normal control, DC-diabetic control, PC-positive control treated with metformin, VML-received V. myrtillus leaf extract, VMLF-received VML and fruit extract, VCL-received V. corymbosum leaf extract, and VCLF-received VCL and fruit extract. Body weight and glucose levels were monitored every second week. After 8 weeks of treatment, serum glucose, insulin, and malondialdehyde were measured. Lenses were removed after sacrifice and eight lenses from each group were randomly selected for evaluation of cataract development. A decrease in body weight was observed in all diabetic groups in the first weeks. In the VML group, no significant decrease was observed. Glucose levels during the experiment were high in DC, PC, and VCL groups, with no improvement during the 8 weeks. In VML, VMLF, and VCLF groups, a decrease in blood glucose levels was observed. Similar results regarding serum insulin and glucose levels at the end of the experiment were observed within groups. V. myrtillus extracts prevented the development of cataract compared with the DC group (P < .05).

KEYWORDS:

bilberry; blueberry; cataract; diabetes; streptozotocin

PMID:
29847743
DOI:
10.1089/jmf.2017.0141
[Indexed for MEDLINE]

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