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J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1560-1567. doi: 10.1093/gerona/gly124.

Impact of a Multidomain Intensive Lifestyle Intervention on Complaints About Memory, Problem-Solving, and Decision-Making Abilities: The Action for Health in Diabetes Randomized Controlled Clinical Trial.

Author information

1
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
2
Division of Preventive Medicine, University of Alabama at Birmingham.
3
Institute for Dementia Research and Prevention, Pennington Biomedical Research Center, Baton Rouge, Los Angeles.
4
Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina.
5
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis.
6
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis.
7
Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
8
Department of Psychiatry and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Abstract

Background:

Lifestyle interventions to reduce weight and increase activity may preserve higher-order cognitive abilities in overweight/obese adults with type 2 diabetes (T2D).

Methods:

Adults (N = 5,084) with T2D who enrolled in a randomized clinical trial of a 10-year intensive lifestyle intervention (ILI) compared with diabetes support and education were queried at baseline and repeatedly during follow-up for complaints about difficulties in memory, problem-solving, and decision-making abilities.

Results:

For those without baseline complaints, assignment to ILI was associated with lower odds that complaints would emerge during follow-up for decision-making ability (odds ratio [OR]=0.851, [95% CI, 0.748,0.967], p=0.014), and, among individuals who were not obese, lower odds that complaints would emerge about problem-solving ability (OR=0.694 [0.510,0.946]). No cognitive benefits from ILI were seen for individuals with baseline complaints about cognitive abilities. ILI may have exacerbated the severity of complaints about problem-solving ability during follow-up among individuals with baseline complaints and cardiovascular disease (OR=2.949 [1.378,6.311]).

Conclusions:

A long-term multidomain ILI may reduce the likelihood that complaints about difficulties in higher-order cognitive abilities will emerge in T2D adults without pre-existing complaints. Among those with pre-existing complaints, the ILI did not prevent increases in complaint severity.

PMID:
29846553
PMCID:
PMC6175017
[Available on 2019-10-08]
DOI:
10.1093/gerona/gly124
[Indexed for MEDLINE]
Free PMC Article

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