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Crit Rev Food Sci Nutr. 2018 May 30:1-20. doi: 10.1080/10408398.2018.1481012. [Epub ahead of print]

Neuro-nutrients as anti-alzheimer's disease agents: A critical review.

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a Department of Biotechnology , College of Agriculture, University of Agriculture Sciences , Bangalore , Hassan , Karnataka , India.
b Institute of Molecular Biosciences, Mahidol University , Nakhon Pathom , Thailand.
c Centre National de la Recherche Scientifique , Paris , France.


Alzheimer's disease (AD) is characterized by a massive neuronal death causing memory loss, cognitive impairment and behavioral alteration that ultimately lead to dementia and death. AD is a multi-factorial pathology controlled by molecular events such as oxidative stress, protein aggregation, mitochondrial dysfunction and neuro inflammation. Nowadays, there is no efficient disease-modifying treatment for AD and epidemiological studies have suggested that diet and nutrition have a significant impact on the development of this disorder. Indeed, some nutrients can protect all kind of cells, including neurons. As prevention is better than cure, life style improvement, with a special emphasis on diet, should seriously be considered as an anti-AD track and intake of nutrients promoting neuronal health is the need of the hour. Diets rich in unsaturated fatty acids, polyphenols and vitamins have been shown to protect against AD, whereas saturated fatty acids-containing diets deprived of polyphenols promote the development of the disease. Thus, Mediterranean diets, mainly composed of fruits, vegetables and omega-3 fatty acids, stand as valuable, mild and preventive anti-AD agents. This review focuses on our current knowledge in the field and how one can fight this devastating neurodegenerative disorder through the simple proper modification of our life style.


Alzheimer's disease; diet; mediterranean diet; neuroprotection; nutrition; polyphenols; vitamins

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