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Chem Commun (Camb). 2018 Jun 12;54(48):6181-6183. doi: 10.1039/c8cc02290a.

Optochemical control of gene expression by photocaged guanine and riboswitches.

Author information

1
Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904 0495, Japan. yohei.yokobayashi@oist.jp.

Abstract

Optical control of biomolecules via engineered proteins or photoactive small molecules has had a profound impact on biology. However, optochemical tools to control RNA functions in living cells are relatively limited. We synthesized a photoactivatable (photocaged) guanine to modulate gene expression under riboswitch control in both mammalian cells and Escherichia coli by light.

PMID:
29845982
DOI:
10.1039/c8cc02290a
[Indexed for MEDLINE]

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