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J Cardiovasc Transl Res. 2018 Oct;11(5):366-374. doi: 10.1007/s12265-018-9811-3. Epub 2018 May 29.

The Application of Induced Pluripotent Stem Cells in Cardiac Disease Modeling and Drug Testing.

Ye L1, Ni X1, Zhao ZA1,2, Lei W1,2, Hu S3,4.

Author information

1
Institute for Cardiovascular Science & Department of Cardiovascular Surgery of First Affiliated Hospital, Medical College, Soochow University, Suzhou, 215000, China.
2
Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology, 215000, Suzhou, China.
3
Institute for Cardiovascular Science & Department of Cardiovascular Surgery of First Affiliated Hospital, Medical College, Soochow University, Suzhou, 215000, China. shijunhu@suda.edu.cn.
4
Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology, 215000, Suzhou, China. shijunhu@suda.edu.cn.

Abstract

In recent decades, cardiovascular diseases have become the greatest health threat to human beings, and thus it is particularly important to explore the subtle underlying pathogenesis of cardiovascular diseases. Although many molecular pathways have been explored to be essential in the development of cardiovascular diseases, their clinical significances are still uncertain. With the emergence of induced pluripotent stem cells (iPSCs), a unique platform for cardiovascular diseases has been established to model cardiovascular diseases on specific genetic background in vitro. This review summarizes current progresses of iPSCs in cardiovascular disease modeling and drug testing. This review highlighted iPSC-based cardiovascular disease modeling and drug testing. The technical advances in iPSC-based researches and various clinically relevant applications are discussed. With further intensive research, iPSC technology will shape the future of clinical translational research in cardiovascular diseases.

KEYWORDS:

Cardiovascular diseases; Disease modeling; Drug testing; Induced pluripotent stem cells

PMID:
29845439
DOI:
10.1007/s12265-018-9811-3

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