Format

Send to

Choose Destination
Iran J Pharm Res. 2017 Winter;16(Suppl):112-118.

Efficacy of Supportive Therapy of Allergic Rhinitis by Stinging Nettle (Urtica dioica) root extract: a Randomized, Double-Blind, Placebo- Controlled, Clinical Trial.

Author information

1
Ear, Nose and Throat Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Allergy Research Center, Ghaem Hospital Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Nanotechnology Research Centre, School Pharmacy,Mashhad University of Medical Sciences, Mashhad, Iran.
6
Community Medicine Department, Faculty of Medicine Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

The aim of this study was to survey the exact benefit of this herb in the management of clinical and laboratory signs and symptoms of allergic rhinitis. In a randomized double blind clinical trial, 74 patients with the signs and symptoms of allergic rhinitis and a positive skin prick test were selected and randomly divided into 2 groups who were takenUrtica dioica 150-mg, Urtidin® F.C Tablet) or placebo for one month. Their signs and symptoms, eosinophil percentage on nasal smear, serum IgE, and interleukin IL-4, IL-5, interferon- γ) levels were recorded. Forty patients completed the trial. Based on the Sino- Nasal Outcome Test 22 SNOT-22), a significant improvement in clinical symptom severity was observed in both groups P < .001). Furthermore, a statistically significant reduction in mean nasal smear eosinophil count was observed after treatment with Nettle P < .01). However, the mean IgE and IL4 and IL5 levels in the study group before and after treatment with Nettle saw no significant changes P > .1). Intergroup pre- and post-treatment laboratory findings suggested that there was a significant difference in post-treatment changes of mean IFN γ levels between the study and placebo group P = 0.017). Although the current study showed certain positive effects of Nettle in the management of allergic rhinitis on controlling the symptoms based on the SNOT-22, similar effects were demonstrated by placebo as well. We believe that our limitations underscore the need for larger, longer term studies of Nettle for the treatment of allergic rhinitis.

KEYWORDS:

Nettle; Urtica Dioica; allergic rhinitis; cytokine

PMID:
29844782
PMCID:
PMC5963652

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center