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Eur J Pharmacol. 1985 Jan 8;107(3):359-62.

P1-purinoceptors mediate relaxation of the bovine bronchial artery.

Abstract

Adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate (AMP) and adenosine all relaxed the bronchial artery. All four purines tested were more efficacious than isoproterenol. Dipyridamole (10(-6) M) enhanced the relaxations due to adenosine and ATP while theophylline (10(-6) M) inhibited the relaxations due to adenosine and ATP. The results suggest the presence of P1-type purinoceptors in the bronchial artery of cattle.

PMID:
2984013
DOI:
10.1016/0014-2999(85)90262-6
[Indexed for MEDLINE]

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