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FEBS Lett. 1985 Jan 28;180(2):249-52.

Proteolysis of mitochondria in reticulocytes during maturation is ubiquitin-dependent and is accompanied by a high rate of ATP hydrolysis.


The ATP-dependent breakdown of mitochondria-containing stroma proceeds via the ubiquitin-requiring pathway. The proteolysis is linked to a large ATP-cleaved consumption amounting to 1 ATP per peptide bond or more. Proteins of mitochondria-containing stroma are much better substrates of ATP-ubiquitin-dependent proteolysis than heat-denatured ones. Hemin suppresses both proteolysis and ATP hydrolysis.

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