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Br J Haematol. 2018 Aug;182(3):423-426. doi: 10.1111/bjh.15404. Epub 2018 May 29.

Detection of platelet autoantibodies to identify immune thrombocytopenia: state of the art.

Author information

1
Immunohaematology Diagnostic Services, Sanquin Diagnostic Services, Amsterdam, the Netherlands.
2
Department of Internal Medicine, HagaZiekenhuis, Den Haag, the Netherlands.
3
Department of Immuno-haematology and Blood Transfusion, Leiden University Medical Centre, Leiden, the Netherlands.
4
Centre for Clinical Transfusion Research, Sanquin Research, Leiden and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.

Abstract

Immune Thrombocytopenia (ITP) is diagnosed by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would support the clinical diagnosis of ITP and prevent misdiagnosis. We optimized our diagnostic algorithm for suspected ITP using the direct monoclonal antibody immobilization of platelet antigens assay (MAIPA), which evaluates the presence of platelet autoantibodies on the glycoproteins (GP) IIb/IIIa, Ib/IX and V bound on the patient platelets. The direct MAIPA was shown to be a valuable technique for the detection of platelet autoantibodies and could possibly become a guide for optimizing therapy towards a more personalized treatment of ITP.

KEYWORDS:

ITP ; MAIPA ; Immune thrombocytopenia; autoantibodies

PMID:
29808904
DOI:
10.1111/bjh.15404
[Indexed for MEDLINE]

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