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Cell Mol Biol (Noisy-le-grand). 2018 May 15;64(6):48-52.

Visfatin increases miR-21 to promote migration in HCC.

Author information

1
The fourth inpatient area of digestive department, Central Hospital of Suining, Suining 629000, China.
2
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.

Abstract

Hepatocellular carcinoma (HCC) is a common human malignancy. In this study, we aimed to investigate the serum levels of visfatin and miR-21 in HCC patients, to analysis the relationship between the pathological features and the plasma level of visfatin or miR-21, and to explore the roles of visfatin and miR-21 in migration of HCC cells. Our results showed that the serum levels of visfatin and miR-21 were significant higher in HCC patients than healthy subjects. The diagnostic sensitivity of serum visfatin was 82.5% and the specificity was 65.0%. The serum visfatin was significantly associated with the histology and metastasis. Visfatin induced miR-21 expression and cell migration in HepG2 cells. Transfection of miR-21 inhibitor suppressed the visfatin-induced migration in HCC cells. These results suggested that visfatin induced HCC cell migration via upregulation of miR-21, which provides a novel basis for the diagnosis of HCC.

KEYWORDS:

HCC; HepG2; Metastasis.; Visfatin; miR-21

PMID:
29808800
[Indexed for MEDLINE]

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