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J Perinatol. 2018 Jul;38(7):908-916. doi: 10.1038/s41372-017-0020-8. Epub 2018 May 29.

Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm.

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Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
Department of Psychology and Neuroanatomy, Boston University, Boston, USA.
Department of Neurology, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Neuroepidemiology Unit, Boston Children's Hospital, Boston, MA, USA.
Department of Pediatrics, Rainbow Babies & Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, Boston, MA, USA.
Department of Psychiatry and Pediatrics, UMASS Medical School/ University of Massachusetts Memorial Children's Medical Center, Worcester, MA, USA.
Department of Radiology, Boston Medical Center, Boston University, Boston, USA.



To describe the accuracy of the Bayley Scales of Infant Development-Second Edition (BSID-II) Mental Development Index (MDI) at 2 years of age for prediction of cognitive function at school age of children born extremely preterm.


Study participants were enrolled in the Extremely Low Gestational Age Newborn Study between 2002 and 2004. Two-thirds of surviving children (nā€‰=ā€‰795) were assessed at 2 years with the BSID-II and at 10 years with an intelligence quotient (IQ) test. We computed test characteristics for a low MDI (<70), including predictive value positive.


Almost two-thirds of children with a low MDI had a normal IQ (ā‰„ā€‰70) at 10 years. Concordance between MDI and IQ was highest among children with major motor and/or sensory impairment, and when MDI was adjusted for gestational age.


Most children born extremely preterm with low BSID-II MDI at 2 years have normal intelligence at school age.

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