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Gynecol Oncol. 2018 Aug;150(2):300-305. doi: 10.1016/j.ygyno.2018.05.022. Epub 2018 May 26.

Pre-operative assessment and post-operative outcomes of elderly women with gynecologic cancers, primary analysis of NRG CC-002: An NRG oncology group/gynecologic oncology group study.

Author information

1
Department of OB/GYN, Division of Gyn Oncology, Rush University Medical Center, Chicago, IL 60612, United States. Electronic address: amina_ahmed@rush.edu.
2
NRG Oncology, Clinical Trial Development Division, Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY 4263, United States. Electronic address: wdeng@gogstats.org.
3
Department of Internal Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, United States. Electronic address: teww@mskcc.org.
4
Gyn/Onc Division, University of Iowa, Iowa City, IA 52242, United States. Electronic address: david-bender@uiowa.edu.
5
Department of OB/GYN, University of Oklahoma, Oklahoma City, OK 73190, United States. Electronic address: Robert-Mannel@ouhsc.edu.
6
Kaiser Permanente Northern California Gynecologic Cancer Program, San Francisco, CA 94115, United States. Electronic address: ramey.littell@kp.org.
7
Department of Radiation Oncology, Main Line Hospital, Wynnewood, PA 19096, United States. Electronic address: dnittisa@mlhs.org.
8
Hanjani Institute for Gynecologic Oncology, Abington Hospital, Jefferson Health, Abington, PA 19001, United States. Electronic address: mitchell.edelson@jefferson.edu.
9
Department of OB/GYN, University of Pennsylvania Hospital System, Philadelphia, PA 19104, United States. Electronic address: mark.a.morgan@uphs.upenn.edu.
10
Cancer Research for the Ozarks, Springfield, MO 65804, United States. Electronic address: jay.carlson@mercy.net.
11
Division of Gynecologic Oncology, Maine Medical Center, Scarborough, ME 04074, United States. Electronic address: darusc@mmc.org.
12
Department of Gynecologic Oncology, Women's Cancer Center of Nevada, Las Vegas, NV 89169, United States. Electronic address: afleury@wccenter.com.
13
Department of OB/GYN, University of Virginia, Charlottesville, VA 22908, United States. Electronic address: scm6h@virginia.edu.
14
Department of Obstetrics & Gynecology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, United States. Electronic address: olawaiyea@mail.magee.edu.
15
Marshfield Clinic, OB-GYN Dept, Marshfield, WI 54449, United States. Electronic address: evans.anthony@marshfieldclinic.org.
16
Section of Medical Oncology, University of Chicago, Chicago, IL 60637, United States. Electronic address: gfleming@medicine.bsd.uchicago.edu.

Abstract

INTRODUCTION:

CC-002 is a prospective cooperative group study conducted by NRG Oncology to evaluate whether a pre-operative GA-GYN score derived from a predictive model utilizing components of an abbreviated geriatric assessment (GA) is associated with major post-operative complications in elderly women with suspected ovarian, fallopian tube, primary peritoneal or advanced stage papillary serous uterine (GYN) carcinoma undergoing primary open cytoreductive surgery.

METHODS:

Patients 70 years or older with suspected advanced gynecologic cancers undergoing evaluation for surgery were eligible. A GA-GYN score was derived from a model utilizing the GA as a pre-operative tool. Patients were followed for six weeks post-operatively or until start of chemotherapy. Post-operative events were recorded either directly as binary occurrence (yes or no) using CTCAE version 4.0.

RESULTS:

There were 189 eligible patients, 117 patients with primary surgical intervention and 37 patients undergoing interval cytoreduction surgery. The association between higher GA-GYN score and major postoperative complications in patients undergoing primary surgery was not significant (p = 0.1341). In a subgroup analysis of patients with advanced staged malignant disease who underwent primary cytoreductive surgery, there was a trend towards an association with the GA-GYN score and post-operative complications.

CONCLUSION:

The pre-operative GA-GYN score derived from a predictive model utilizing components of an abbreviated geriatric assessment was not predictive of major post-operative complications in elderly patients undergoing primary open cytoreductive surgery. However, there was an association between GA-GYN score and post-operative complications in a subgroup of patients with advanced staged malignant disease.

KEYWORDS:

Gynecologic cancers; NRG-CC002; Post-operative outcomes

PMID:
29807694
PMCID:
PMC6387790
[Available on 2019-08-01]
DOI:
10.1016/j.ygyno.2018.05.022
[Indexed for MEDLINE]

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