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Surgery. 2018 Aug;164(2):178-184. doi: 10.1016/j.surg.2018.04.011. Epub 2018 May 26.

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.

Author information

1
Department of Surgery, University of Florida College of Medicine, Gainesville. Electronic address: philip.efron@surgery.ufl.edu.
2
Department of Surgery, University of Florida College of Medicine, Gainesville.
3
Department of Medicine, University of Florida College of Medicine, Gainesville.
4
Department of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville.
5
Institute on Aging and the Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainseville.

Abstract

As early as the 1990s, chronic critical illness, a distinct syndrome of persistent high-acuity illness requiring management in the ICU, was reported under a variety of descriptive terms including the "neuropathy of critical illness," "myopathy of critical illness," "ICU-acquired weakness," and most recently "post-intensive care unit syndrome." The widespread implementation of targeted shock resuscitation, improved organ support modalities, and evidence-based protocolized ICU care has resulted in significantly decreased in-hospital mortality within surgical ICUs, specifically by reducing early multiple organ failure deaths. However, a new phenotype of multiple organ failure has now emerged with persistent but manageable organ dysfunction, high resource utilization, and discharge to prolonged care facilities. This new multiple organ failure phenotype is now clinically associated with the rapidly increasing incidence of chronic critical illness in critically ill surgery patients. Although the underlying pathophysiology driving chronic critical illness remains incompletely described, the persistent inflammation, immunosuppression, and catabolism syndrome has been proposed as a mechanistic framework in which to explain the increased incidence of chronic critical illness in surgical ICUs. The purpose of this review is to provide a historic perspective of the epidemiologic evolution of multiple organ failure into persistent inflammation, immunosuppression, and catabolism syndrome; describe the mechanism that drives and sustains chronic critical illness, and review the long-term outcomes of surgical patients who develop chronic critical illness.

PMID:
29807651
PMCID:
PMC6056337
[Available on 2019-08-01]
DOI:
10.1016/j.surg.2018.04.011
[Indexed for MEDLINE]

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