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Lipids Health Dis. 2018 May 28;17(1):126. doi: 10.1186/s12944-018-0767-8.

Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, 1163 Xinmin Street, Changchun, 130021, China.
2
The Cardiovascular Center, the First Hospital of Jilin University, Changchun, 130021, China.
3
Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, 1163 Xinmin Street, Changchun, 130021, China. ywliu@jlu.edu.cn.

Abstract

BACKGROUND:

Inconsistencies have existed in research findings on the association between cardiovascular disease (CVD) and single nucleotide polymorphisms (SNPs) of ADIPOQ, triggering this up-to-date meta-analysis.

METHODS:

We searched for relevant studies in PubMed, EMBASE, Cochrane Library, CNKI, CBM, VIP, and WanFang databases up to 1st July 2017. We included 19,106 cases and 31,629 controls from 65 published articles in this meta-analysis. STATA 12.0 software was used for all statistical analyses.

RESULTS:

Our results showed that rs266729 polymorphism was associated with the increased risk of CVD in dominant model or in heterozygote model; rs2241766 polymorphism was associated with the increased risk of CVD in the genetic models (allelic, dominant, recessive, heterozygote, and homozygote). In subgroup analysis, significant associations were found in different subgroups with the three SNPs. Meta-regression and subgroup analysis showed that heterogeneity might be explained by other confounding factors. Sensitivity analysis revealed that the results of our meta-analysis were stable and robust. In addition, the results of trial sequential analysis showed that evidences of our results are sufficient to reach concrete conclusions.

CONCLUSIONS:

In conclusion, our meta-analysis found significant increased CVD risk is associated with rs266729 and rs2241766, but not associated with rs1501299.

KEYWORDS:

ADIPOQ; Association; Cardiovascular disease; Meta-analysis; Single nucleotide polymorphisms

PMID:
29807528
PMCID:
PMC5972450
DOI:
10.1186/s12944-018-0767-8
[Indexed for MEDLINE]
Free PMC Article

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