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Psychiatry Res Neuroimaging. 2018 Jul 30;277:39-44. doi: 10.1016/j.pscychresns.2018.05.004. Epub 2018 May 12.

Anterior thalamic radiation structural and metabolic changes in obsessive-compulsive disorder: A combined DTI-MRS study.

Author information

1
Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
2
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030,China. Electronic address: fanqing_98@sina.com.
3
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030,China.
4
Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China. Electronic address: yaoli@sjtu.edu.cn.

Abstract

Numerous studies indicate the cortico-striato-thalamo-cortical (CSTC) circuit plays an important role in the pathophysiology of obsessive-compulsive disorder (OCD). The anterior thalamic radiation (ATR), as a major fiber in the fronto-thalamic circuitry, contributes to symptomology of OCD. However, the underlying biochemical mechanism in relation with its structural alteration remains not understood. This study investigated the structural abnormality of ATR and its correlation with thalamic metabolic alteration in OCD, using diffusion tensor image (DTI) and proton magnetic resonance spectroscopy (1H-MRS). Twenty-six unmedicated adult OCD patients and twenty-six matched healthy controls participated in DTI study. Thirteen OCD patients and thirteen healthy controls, a subset of DTI participants, took part in MRS study. The results showed that mean fiber length of right ATR negatively correlated with ipsilateral thalamic choline (Cho) level in OCD patients. Additionally, significantly higher Cho concentration was detected in right thalamus of OCD patients compared to healthy controls. Moreover, the mean fractional anisotropy (FA) value of right ATR positively correlated with patients Yale-Brown Obsessive Compulsive Scale (YBOCS) total score, as well as YBOCS compulsion score. These results suggested the coupling of structural and metabolic changes in right ATR, which might serve as a multi-modal biomarker contributing to the pathogenesis of OCD.

KEYWORDS:

Anterior thalamic radiation; Choline; Diffusion tensor image; Magnetic resonance spectroscopy; Obsessive-compulsive disorder

[Indexed for MEDLINE]

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