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Mol Clin Oncol. 2018 Jun;8(6):725-728. doi: 10.3892/mco.2018.1604. Epub 2018 Apr 12.

18F-fluorodeoxyglucose imaging of primary malignant pericardial mesothelioma with concurrent pericardial and pleural effusions and bone metastasis: A case report.

Author information

1
Department of Radiology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, P.R. China.
2
Department of Urinary Surgery, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, P.R. China.
3
Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, P.R. China.
4
Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, P.R. China.

Abstract

Primary malignant pericardial mesothelioma (PMPM) is an aggressive tumor that originates from the mesothelial cells of the pericardium. PMPM with extensive atrial infiltration and bone metastasis is extremely rare. The diagnosis and staging of PMPM based on anatomical imaging may be difficult when concurrent pericardial and pleural effusions are present. A 28-year-old man presented with progressive chest pain. Concurrent pericardial and pleural effusions were identified on computed tomography. On echocardiography, mild thickening and adhesions of the pericardium with the right ventricle and atrium were observed. 18F-fluorodeoxyglucose (FDG) metabolism imaging revealed increased accumulation in the pericardium and adjacent right atrium. Ring-shaped radioactivity aggregation and bone destruction in the sacrum were demonstrated on 18F-FDG and 99mTc-methyl diphosphonate imaging. The diagnosis of PMPM was subsequently confirmed by pathology. The patient survived for >1.5 years with comprehensive treatment.

KEYWORDS:

18F-fluorodeoxyglucose; 99mTc-methyl diphosphonate; computed tomography; pleural effusion; primary malignant pericardial mesothelioma

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