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Trends Mol Med. 2018 Jul;24(7):607-614. doi: 10.1016/j.molmed.2018.05.005. Epub 2018 May 24.

Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling.

Author information

1
Université Côte d'Azur, Institut National de la Santé et de la Recherche Médicale (INSERM) Centre Méditerranéen de Médecine Moléculaire (C3 M), Nice, France.
2
INSERM Unité 1242 Chemistry, Oncogenesis, Stress, Signaling, Université Rennes 1, Rennes, France; Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France.
3
Université Côte d'Azur, Institut National de la Santé et de la Recherche Médicale (INSERM) Centre Méditerranéen de Médecine Moléculaire (C3 M), Nice, France. Electronic address: ricci@unice.fr.

Abstract

The ability of a tumor cell to cope with environmental and intracellular stress depends on its capacity to activate appropriate adaptive pathways. As such, the endoplasmic reticulum (ER) adjusts the adaptive capacity of tumor cells by engaging the unfolded protein response (UPR). The UPR maintains the functionality of the secretory pathway, thereby allowing tumor cells to shape their microenvironment, thus likely determining the nature of the tumor immune response. Consequently, this makes the UPR very relevant in the context of cancer therapeutics. We focus here on inositol-requiring enzyme 1α (IRE1) and compile novel molecular mechanisms demonstrating that tumoral UPR controls the tumor microenvironment (TME) and the immune response, therefore opening potential novel therapeutic avenues.

KEYWORDS:

cancer; endoplasmic reticulum; immune response; nutrition; stress

PMID:
29804923
DOI:
10.1016/j.molmed.2018.05.005
[Indexed for MEDLINE]

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