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J Diabetes. 2018 Dec;10(12):958-964. doi: 10.1111/1753-0407.12784. Epub 2018 Jun 27.

Negative association between serum aryl hydrocarbon receptor concentrations and β-cell function in patients with no history of diabetes undergoing coronary angiography.

Wang JS1,2, Lee WJ3, Lee IT1,4,5, Lin SY1,4, Lee WL4,6, Liang KW4,5,6, Lin SJ2,7,8,9, Sheu WH1,4,10,11.

Author information

1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
2
Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
3
Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
4
Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
5
Department of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
6
Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
7
Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
8
Taipei Medical University, Taipei, Taiwan.
9
Healthcare and Services Center, Taipei Veterans General Hospital, Taipei, Taiwan.
10
Institute of Medical Technology, College of Life Science, National Chung-Hsing University, Taichung, Taiwan.
11
School of Medicine, National Defense Medical Center, Taipei, Taiwan.

Abstract

BACKGROUND:

The aim of the present study was to investigate the association between serum aryl hydrocarbon receptor (AhR) levels and insulin resistance and β-cell function in patients undergoing coronary angiography with no history of diabetes.

METHODS:

Patients with no history of diabetes who had undergone coronary angiography underwent an oral glucose tolerance test (OGTT) 2-4 weeks after discharge from hospital; blood samples were collected for measurements of glucose, insulin, and AhR. Patients' glucose regulation status was determined on the basis of the OGTT. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). β-Cell function was assessed using the insulinogenic index (IGI).

RESULTS:

The study included 473 patients (mean (±SD) age 61 ±12 years, 81.8% male, mean body mass index 26.1 ±3.6 kg/m2 ). Overall, mean serum AhR concentrations were 25.1 ±12.2 pg/mL. Patients with normal glucose tolerance had a lower serum AhR concentrations than patients with prediabetes or newly diagnosed diabetes (23.4 ±10.8 vs 26.2 ±13.2 and 26.9 ±12.3 pg/mL, respectively; P = 0.029). Linear regression analysis revealed that serum AhR concentrations were not associated with HOMA-IR, but were negatively associated with IGI after adjustment for several confounders, including HOMA-IR (β = -0.162; 95% confidence interval - 0.302, -0.022; P = 0.023).

CONCLUSIONS:

In patients with no history of diabetes, serum AhR concentrations were negatively associated with β-cell function, independent of several confounders, including insulin resistance.

KEYWORDS:

aryl hydrocarbon receptor; diabetes; oral glucose tolerance test; β-cell function; β细胞功能; 口服葡萄糖耐量试验; 糖尿病; 芳香烃受体

PMID:
29802768
DOI:
10.1111/1753-0407.12784
[Indexed for MEDLINE]

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