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Genes Dev. 2018 May 1;32(9-10):620-638. doi: 10.1101/gad.314351.118.

The impact of mitotic errors on cell proliferation and tumorigenesis.

Author information

1
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Abstract

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic stability. Recent work has provided insight into how mitotic errors shape cancer genomes by driving both numerical and structural alterations in chromosomes that contribute to tumor initiation and progression. Here, we review the sources of mitotic errors in human tumors and their effect on cell fitness and transformation. We discuss new findings that suggest that chromosome missegregation can produce a proinflammatory environment and impact tumor responsiveness to immunotherapy. Finally, we survey the vulnerabilities exposed by cell division errors and how they can be exploited therapeutically.

KEYWORDS:

aneuploidy; chromosomal instability; mitosis

PMID:
29802124
PMCID:
PMC6004076
DOI:
10.1101/gad.314351.118
[Indexed for MEDLINE]
Free PMC Article

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