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Genes Dev. 2018 May 1;32(9-10):602-619. doi: 10.1101/gad.314674.118.

Regulation of lipid peroxidation and ferroptosis in diverse species.

Author information

1
Institute of Developmental Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), 85764 Neuherberg, Germany.
2
Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
3
Department of Environmental Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
4
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
5
Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
6
Laboratory of Navigational Lipidomics of Cell Death and Regeneration, I.M. Sechenov First Moscow State Medical University, Moscow 119992, Russia.
7
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
8
Instituto de Investigaciones Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Mar del Plata, 7600 Mar del Plata, Argentina.
9
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97330.
10
Molecular and Cell Biology Graduate Program, Oregon State University, Corvallis, Oregon 97330, USA.
11
College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon 97330, USA.
12
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
13
Department of Chemistry, Columbia University, New York, New York 10027, USA.

Abstract

Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.

KEYWORDS:

ROS; cell death; ferroptosis; iron; lipid peroxidation; vitamin E

PMID:
29802123
PMCID:
PMC6004068
DOI:
10.1101/gad.314674.118
[Indexed for MEDLINE]
Free PMC Article

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