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Parkinsonism Relat Disord. 2018 Oct;55:75-80. doi: 10.1016/j.parkreldis.2018.05.012. Epub 2018 May 23.

Mortality from Parkinson's disease in China: Findings from a ten-year follow up study in Shanghai.

Author information

1
Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai, Jiao Tong University School of Medicine, Shanghai, 200025, China.
2
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China.
3
School of Public Health, Shanghai Jiao Tong University, Shanghai, 200025, China. Electronic address: xugang567@sina.com.
4
Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai, Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address: wg11424@rjh.com.cn.

Abstract

BACKGROUND:

Standardized mortality ratio (SMR) is the most frequently used index in Parkinson's disease (PD) survival survey. However, there is little SMR data in PD from China.

OBJECTIVE:

To examine the outcome, including overall and cause-specific mortality, of PD patients subsequent to 10 years of surveillance in Shanghai, China. This is an extension study of our previous investigation on mortality.
 METHODS: One hundred fifty-seven PD patients recruited from the movement disorder clinic of Rui Jin Hospital in 2006 were followed up until December 31, 2016 or death, representing a follow-up period of up to 10 years. Overall and cause-specific standardized mortality ratios (SMR) were calculated, and predictors for survival at disease onset were estimated.
 RESULTS: Thirty one patients had died by December 31, 2016, and the SMR at 10 years of follow-up was 0.87 (0.59-1.25). The primary direct cause of death was respiratory disease (SMR = 3.52, 95% CI 1.98-5.78). Employing Cox's proportional hazard modeling, postural instability gait disorder (PIGD) type and older age at onset predicted poor survival in this cohort.

CONCLUSIONS:

This finding confirms the similar survival of patients with PD to the control population in the post-levodopa era. PIGD type and older age at onset had a negative impact on survival.

KEYWORDS:

Mortality; Parkinson's disease; Standardized mortality ratio

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