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Prog Cardiovasc Dis. 2018 May - Jun;61(1):33-37. doi: 10.1016/j.pcad.2018.05.003. Epub 2018 May 22.

Nuts and Cardiovascular Disease.

Author information

1
Center for Nutrition, Lifestyle and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA 92350, United States; Department of Nutrition & Dietetics, School of Allied Health Professions, Loma Linda University, Loma Linda, CA 92350, United States. Electronic address: ebitok@llu.edu.
2
Center for Nutrition, Lifestyle and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA 92350, United States.

Abstract

There is compelling evidence showing that nut intake confers protection against cardiovascular disease (CVD). We conducted a review of the literature with respect to observational studies and randomized trials completed in the past ≈25 years that examined nut intake and CVD endpoints. We included findings from major cohort studies, a large intervention trial, and numerous smaller nut trials. Collectively, data from observational and intervention studies indicate strong and significant association between nut intake and decreased risk of fatal and non-fatal coronary heart disease, myocardial infarction, and sudden death; and somewhat weak association with stroke. The primary mechanism by which nuts protect against CVD is through the improvement of lipid and apolipoprotein profile. Increasing evidence also indicates that nut consumption may confer protection against CVD via lowering of oxidative stress, inflammation, and improvement in endothelial function. Nut components, such as unsaturated fatty acids, l-arginine, beneficial minerals, phenolic compounds and phytosterols, appear to be of paramount importance for their health effects.

KEYWORDS:

Cardiovascular disease; Coronary heart disease; Endothelial function; Inflammation; Mortality; Nuts; Oxidative stress

PMID:
29800597
DOI:
10.1016/j.pcad.2018.05.003
[Indexed for MEDLINE]

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