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Nutrients. 2018 May 25;10(6). pii: E673. doi: 10.3390/nu10060673.

An 8-Week Ketogenic Low Carbohydrate, High Fat Diet Enhanced Exhaustive Exercise Capacity in Mice.

Ma S1, Huang Q2,3,4, Yada K5,6, Liu C7,8, Suzuki K9.

Author information

1
Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan. masihui@toki.waseda.jp.
2
Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan. hqyaaaaaa@163.com.
3
College of Food Science, South China Agricultural University, Guangzhou 510642, China. hqyaaaaaa@163.com.
4
The Key Laboratory of Food Quality and Safety of Guangdong Province, Guangzhou 510642, China. hqyaaaaaa@163.com.
5
Research Organization for Nano and Life Innovation, Waseda University, Tokorozawa 359-1192, Japan. yada_koich@yahoo.co.jp.
6
Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan. yada_koich@yahoo.co.jp.
7
College of Food Science, South China Agricultural University, Guangzhou 510642, China. liuch@scau.edu.cn.
8
The Key Laboratory of Food Quality and Safety of Guangdong Province, Guangzhou 510642, China. liuch@scau.edu.cn.
9
Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan. katsu.suzu@waseda.jp.

Abstract

Current fueling tactics for endurance exercise encourage athletes to ingest a high carbohydrate diet. However, athletes are not generally encouraged to use fat, the largest energy reserve in the human body. A low carbohydrate, high fat ketogenic diet (KD) is a nutritional approach ensuring that the body utilizes lipids. Although KD has been associated with weight-loss, enhanced fat utilization in muscle and other beneficial effects, there is currently no clear proof whether it could lead to performance advantage. To evaluate the effects of KD on endurance exercise capacity, we studied the performance of mice subjected to a running model after consuming KD for eight weeks. Weight dropped dramatically in KD-feeding mice, even though they ate more calories. KD-feeding mice showed enhanced running time without aggravated muscle injury. Blood biochemistry and correlation analysis indicated the potential mechanism is likely to be a keto-adaptation enhanced capacity to transport and metabolize fat. KD also showed a potential preventive effect on organ injury caused by acute exercise, although KD failed to exert protection from muscle injury. Ultimately, KD may contribute to prolonged exercise capacity.

KEYWORDS:

endurance exercise capacity; keto-adaptation; ketogenic diet; muscle damage

PMID:
29799502
PMCID:
PMC6024661
DOI:
10.3390/nu10060673
[Indexed for MEDLINE]
Free PMC Article

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