Format

Send to

Choose Destination
Bull Exp Biol Med. 2018 May;165(1):121-126. doi: 10.1007/s10517-018-4112-z. Epub 2018 May 24.

Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia.

Author information

1
Research Institute of Clinical and Experimental Lymphology -Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. aplykov2@mail.ru.
2
Research Institute of Clinical and Experimental Lymphology -Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

Abstract

We studied the effect of intramuscular injections of bone marrow mesenchymal stromal cells on microcirculation parameters in an ischemic limb of Wistar rats. It was shown that transplantation of mesenchymal stem cells with or without erythropoietin stimulates angiogenesis in the ischemic zone. An essential role in angiogenesis stimulation is played by cytokines and growth factors.

KEYWORDS:

critical limb ischemia; cytokines; erythropoietin; mesenchymal stem cells; microcirculation

PMID:
29796803
DOI:
10.1007/s10517-018-4112-z
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center