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J Biol Phys. 2018 Sep;44(3):419-431. doi: 10.1007/s10867-018-9499-2. Epub 2018 May 24.

Is a constant low-entropy process at the root of glycolytic oscillations?

Author information

1
MEMPHYS - International and Interdisciplinary Research Network, Odense M, Denmark.
2
University of Southern Denmark, Institute for Biochemistry and Molecular Biology, Campusvej 55, 5230, Odense M, Denmark.
3
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
4
Membrane Biophysics Group, Niels Bohr Institute University of Copenhagen, Blegdamsvej 17, 2100, Copenhagen, Denmark.
5
MEMPHYS - International and Interdisciplinary Research Network, Odense M, Denmark. lbagatolli@immf.uncor.edu.
6
Instituto de Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET-Universidad Nacional de Córdoba), Friuli 2434, 5016, Córdoba, Argentina. lbagatolli@immf.uncor.edu.

Abstract

We measured temporal oscillations in thermodynamic variables such as temperature, heat flux, and cellular volume in suspensions of non-dividing yeast cells which exhibit temporal glycolytic oscillations. Oscillations in these variables have the same frequency as oscillations in the activity of intracellular metabolites, suggesting strong coupling between them. These results can be interpreted in light of a recently proposed theoretical formalism in which isentropic thermodynamic systems can display coupled oscillations in all extensive and intensive variables, reminiscent of adiabatic waves. This interpretation suggests that oscillations may be a consequence of the requirement of living cells for a constant low-entropy state while simultaneously performing biochemical transformations, i.e., remaining metabolically active. This hypothesis, which is in line with the view of the cellular interior as a highly structured and near equilibrium system where energy inputs can be low and sustain regular oscillatory regimes, calls into question the notion that metabolic processes are essentially dissipative.

KEYWORDS:

Association-induction hypothesis; Glycolytic oscillations; Isentropic process; Onsager’s theory; Temperature oscillations

PMID:
29796745
PMCID:
PMC6082799
[Available on 2019-09-01]
DOI:
10.1007/s10867-018-9499-2

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