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Sci Rep. 2018 May 23;8(1):8047. doi: 10.1038/s41598-018-26446-w.

HDV infection rates in northern Vietnam.

Author information

1
Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
2
Vietnamese-German Center for Excellence in Medical Research, Hanoi, Vietnam.
3
108 Military Central Hospital, Hanoi, Vietnam.
4
Vietnamese Military Medical University, Hanoi, Vietnam.
5
Department. for Gastroenterology and Hepatology Medical Center, University Hospital Essen, Essen, Germany.
6
Faculty of Medicine, Duy Tan University, Da Nang, Vietnam.
7
Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany.
8
Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. velavan@medizin.uni-tuebingen.de.
9
Vietnamese-German Center for Excellence in Medical Research, Hanoi, Vietnam. velavan@medizin.uni-tuebingen.de.
10
Faculty of Medicine, Duy Tan University, Da Nang, Vietnam. velavan@medizin.uni-tuebingen.de.

Abstract

Hepatitis D caused by the hepatitis delta virus (HDV) is a serious health problem in many regions of the world. A total of 546 HBV-infected patients were enrolled from 2013 to 2015 and classified clinically into the subgroups of chronic hepatitis B (CHB, n = 191), liver cirrhosis (LC, n = 147) and hepatocellular carcinoma (HCC, n = 208). The patients were screened for HDV-RNA by nested PCR assays. HDV genotypes were assessed by direct sequencing, followed by phylogenetic analysis. HDV-RNA was identified in 13% (71/546) of HBV-infected patients. The highest HDV prevalence was found in the LC group (19.7%), followed by the HCC (12%) and CHB (8.9%) groups (P = 0.017). HDV/HBV coinfections were significantly associated with a rather unfavourable clinical outcome, in particular with LC development compared to HBV monoinfection. Phylogenetic analyses indicated that the genotype HDV1 was, with a prevalence of 91%, by far the most common genotype in Vietnam, followed by HDV2 with 9%. Other HDV genotypes were not observed. In accordance with previous data obtained a decade ago, our results confirm a continuing high prevalence of HDV infection in hepatitis B patients in northern Vietnam with the HDV1 genotype still being the predominant genotype. HDV nucleic acid testing to minimize the associated risk should be considered.

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