Format

Send to

Choose Destination
J Pediatr. 2018 Sep;200:132-139.e3. doi: 10.1016/j.jpeds.2018.04.073. Epub 2018 May 21.

Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort.

Collaborators (173)

Jobe AH7, Caplan MS8, Polin RA9, Laptook AR10, Hensman AM10, McGowan EC10, Vieira E10, Little E10, Johnson K10, Alksninis B10, Keszler ML10, Knoll AM10, Leach TM10, Watson VE10, Walsh MC11, Fanaroff AA11, Wilson-Costello DE11, Payne A11, Newman NS11, Taylor HG11, Siner BS11, Zadell A11, DiFiore J11, Bhola M11, Friedman HG11, Yalcinkaya G11, Bulas D12, Goldberg RN13, Cotten CM13, Goldstein RF13, Gustafson KE13, Ashley P13, Auten KJ13, Fisher KA13, Foy KA13, Freedman SF13, Lohmeyer MB13, Malcolm WF13, Wallace DK13, Carlton DP14, Stoll BJ14, Adams-Chapman I14, Buchter S14, Piazza AJ14, Carter14, Fritz S14, Hale EC14, Hutchinson AK14, LaRossa MM14, Loggins Y14, Bottcher D14, Archer SW15, Poindexter BB16, Sokol GM16, Harmon HM16, Papile LA16, Hines AC16, Wilson LD16, Herron DE16, Smiley L16, Kennedy KA17, Tyson JE17, Duncan AF17, Dempsey AG17, John J17, Jones PM17, Lillie ML17, Siddiki S17, Sperry DK17, Berberich MA18, Blaisdell CJ18, Gail DB18, Kiley JP18, Wallace D19, Gantz MG19, Newman JE19, Auman JO19, Hammond JA19, Poole WK19, Van Meurs KP20, Stevenson DK20, DeAnda ME20, Ball MB20, Goodlin GT20, Frantz ID 3rd21, Fiascone JM21, McGowan EC21, Furey A21, MacKinnon BL21, Nylen E21, Brussa A21, Sibley C21, Carlo WA22, Ambalavanan N22, Peralta-Carcelen M22, Collins MV22, Cosby SS22, Phillips VA22, Bailey KJ22, Biasini FJ22, Hopkins M22, Johnston KC22, Nelson KG22, Patterson CS22, Rector RV22, Rodriguez L22, Soong A22, Whitley S22, York S22, Guest K22, Smith LA22, Finer NN23, Garey D23, Rasmussen MR23, Wozniak PR23, Vaucher YE23, Fuller MG23, Akshoomoff N23, Rich W23, Arnell K23, Bridge R23, Bell EF24, Colaizy TT24, Widness JA24, Klein JM24, Johnson KJ24, Acarregui MJ24, Eastman DL24, Wilgenbusch TLV24, Watterberg KL25, Ohls RK25, Fuller J25, Lowe J25, Rohr J25, Lacy CB25, Montman R25, Brown S25, Sánchez PJ26, Rosenfeld CR26, Salhab WA26, Brion L26, Adams SS26, Allen J26, Grau L26, Guzman A, Hensley G26, Heyne ET26, Hickman JF26, Leps MH26, Madden LA26, Martin M26, Miller NA26, Morgan JS26, Solis A26, Lee LE26, Boatman CT26, Vasil DM26, Yoder BA27, Faix RG27, Winter S27, Baker S27, Osborne KA27, Rau CA27, Cunningham S27, Ford A27, Shankaran S28, Pappas A28, Sood BG28, Bara R28, Slovis TL28, Billian E28, Goldston LA28, Johnson M28.

Author information

1
Department of Pediatrics, Division of Neonatal Medicine, Women & Infants Hospital and Alpert Medical School of Brown University, Providence, RI. Electronic address: bvohr@wihri.org.
2
Department of Pediatrics, Division of Neonatal Medicine, UT Southwestern, Dallas, TX.
3
Social Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC.
4
Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD.
5
National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD.
6
Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA.
7
University of Cincinnati.
8
Pritzker School of Medicine, University of Chicago.
9
Division of Neonatology, College of Physicians and Surgeons, Columbia University.
10
Rainbow Babies & Children's Hospital, Alpert Medical School of Brown University and Women & Infants Hospital of Rhode Island.
11
Case Western Reserve University.
12
Department of Diagnostic Imaging and Radiology, Children's National Medical Center, Washington, DC.
13
University Hospital, Duke Regional Hospital, Duke University School of Medicine.
14
Children's Healthcare of Atlanta, Grady Memorial Hospital, and Emory Crawford Long Hospital, Emory University.
15
Eunice Kennedy Shriver National Institute of Child Health and Human Development.
16
University Hospital, Methodist Hospital, Riley Hospital for Children, and Wishard Health Services, Indiana University.
17
McGovern Medical School, Children's Memorial Hermann Hospital, The University of Texas Health Science Center at Houston.
18
National Heart, Lung, and Blood Institute.
19
RTI International.
20
Lucile Packard Children's Hospital, Stanford University.
21
Floating Hospital for Children, Tufts Medical Center.
22
University of Alabama at Birmingham Health System and Children's Hospital of Alabama.
23
San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California.
24
University of Iowa.
25
University of New Mexico Health Sciences Center.
26
Parkland Health & Hospital System, and Children's Medical Center Dallas, University of Texas Southwestern Medical Center at Dallas.
27
Intermountain Medical Center, LDS Hospital, Primary Children's Medical Center, University of Utah Medical Center.
28
Hutzel Women's Hospital, Children's Hospital of Michigan, Wayne State University.

Abstract

OBJECTIVE:

To identify rates of overweight (body mass index [BMI] ≥85th percentile) and obesity (BMI ≥95th percentile) at 6-7 years of age and associated risk factors among extremely preterm infants born at <28 weeks of gestation.

STUDY DESIGN:

Anthropometrics, blood pressure, and active and sedentary activity levels were prospectively assessed. Three groups were compared, those with a BMI ≥85th percentile (overweight or obese for age, height, and sex) and ≥95th percentile (obese) vs <85th percentile. Multiple regression analyses estimated the relative risks of BMI ≥85th percentile and ≥95th percentile associated with perinatal and early childhood factors.

RESULTS:

Of 388 children, 22% had a BMI of ≥85th percentile and 10% were obese. Children with obesity and overweight compared with normal weight children had higher body fat (subscapular skinfold and triceps skinfold >85th percentile), central fat (waist circumference >90th percentile), spent more time in sedentary activity (20.5 vs 18.2 vs 16.7 hours/week), and had either systolic and/or diastolic hypertension (24% vs 26% vs 14%), respectively. Postdischarge weight gain velocities from 36 weeks postmenstrual age to 18 months, and 18 months to 6-7 years were independently associated with a BMI of ≥85th percentile, whereas weight gain velocity from 18 months to 6-7 years was associated with obesity.

CONCLUSIONS:

One in 5 former extremely preterm infants is overweight or obese and has central obesity at early school age. Postdischarge weight gain velocities were associated with overweight and obesity. These findings suggest the obesity epidemic is spreading to the most extremely preterm infants.

TRIAL REGISTRATION:

ClinicalTrials.gov: NCT00063063 and NCT0000.

KEYWORDS:

hypertension; obese; overweight; preterm; school age; sedentary activity

PMID:
29793869
PMCID:
PMC6109599
[Available on 2019-09-01]
DOI:
10.1016/j.jpeds.2018.04.073

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center