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J Neuroimmunol. 2019 Apr 15;329:1-8. doi: 10.1016/j.jneuroim.2018.05.006. Epub 2018 May 18.

Does the environment influence multiple sclerosis pathogenesis via UVB light and/or induction of vitamin D?

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Department of Neurology, University of Münster, Münster, Germany.
Department of Dermatology, University of Münster, Münster, Germany.
Department of Neurology, University of Münster, Münster, Germany. Electronic address:


Multiple sclerosis (MS) is a disease of presumed auto-immune origin. Long-standing observations such as the correlation between MS incidence and geographical latitude or the levels of Vitamin D (Vit D) in the serum have implicated the environmental factors UVB radiation and diet in the etiology of the disease. Clinical trials have been conducted and are currently underway to elucidate whether a Vit D enriched diet or treatment with UVB can influence MS incidence, -severity, and -progression, as well as the ideal time point for treatment. This review summarizes the current scientific knowledge to the environmental factors UVB-light and Vit D concerning the clinical aspects of MS in epidemiological studies and clinical trials.


Clinical trials; Multiple sclerosis; UVB light; Vitamin D

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