Format

Send to

Choose Destination
J Chem Inf Model. 2018 Jun 25;58(6):1182-1193. doi: 10.1021/acs.jcim.8b00125. Epub 2018 Jun 7.

Cheminformatic Insight into the Differences between Terrestrial and Marine Originated Natural Products.

Author information

1
College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang 310058 , China.
2
State Key Laboratory of Agricultural Microbiology and Agricultural Bioinformatics, Key Laboratory of Hubei Province, College of Informatics , Huazhong Agricultural University , Wuhan 430070 , China.
3
State Key Lab of CAD&CG , Zhejiang University , Hangzhou , Zhejiang 310058 , China.
4
Department of Pharmaceutical Sciences , University of Pittsburgh , Pittsburgh , Pennsylvania 15261 , United States.

Abstract

This is a new golden age for drug discovery based on natural products derived from both marine and terrestrial sources. Herein, a straightforward but important question is "what are the major structural differences between marine natural products (MNPs) and terrestrial natural products (TNPs)?" To answer this question, we analyzed the important physicochemical properties, structural features, and drug-likeness of the two types of natural products and discussed their differences from the perspective of evolution. In general, MNPs have lower solubility and are often larger than TNPs. On average, particularly from the perspective of unique fragments and scaffolds, MNPs usually possess more long chains and large rings, especially 8- to 10-membered rings. MNPs also have more nitrogen atoms and halogens, notably bromines, and fewer oxygen atoms, suggesting that MNPs may be synthesized by more diverse biosynthetic pathways than TNPs. Analysis of the frequently occurring Murcko frameworks in MNPs and TNPS also reveals a striking difference between MNPs and TNPs. The scaffolds of the former tend to be longer and often contain ester bonds connected to 10-membered rings, while the scaffolds of the latter tend to be shorter and often bear more stable ring systems and bond types. Besides, the prediction from the naïve Bayesian drug-likeness classification model suggests that most compounds in MNPs and TNPs are drug-like, although MNPs are slightly more drug-like than TNPs. We believe that MNPs and TNPs with novel drug-like scaffolds have great potential to be drug leads or drug candidates in drug discovery campaigns.

PMID:
29792805
DOI:
10.1021/acs.jcim.8b00125
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center