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Exp Biol Med (Maywood). 2018 Jun;243(10):836-842. doi: 10.1177/1535370218779024. Epub 2018 May 23.

Maternal nutrition and the developmental origins of osteoporosis in offspring: Potential mechanisms and clinical implications.

Author information

1
1 Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
2
2 Department of Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
3
3 Department of Pediatrics, The Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China.
4
4 Department of Spine Surgery, Tianjin Union Medical Center, Tianjin Institute of Spine, Tianjin 300121, China.

Abstract

Osteoporosis, the most frequent metabolic disorder of bone, is a complex disease with a multifactorial origin that is influenced by genes and environments. However, the pathogenesis of osteoporosis has not been fully elucidated. The theory of "Developmental Origins of Health and Disease" indicates that early life environment exposure determines the risks of cardiometabolic diseases in adulthood. However, investigations into the effects of maternal nutrition and nutrition exposure during early life on the development of osteoporosis are limited. Recently, emerging evidence has strongly suggested that maternal nutrition has long-term influences on bone metabolism in offspring, and epigenetic modifications maybe the underlying mechanisms of this process. This review aimed to address maternal nutrition and its implications for the developmental origins of osteoporosis in offspring. It is novel in providing a theoretical basis for the early prevention of osteoporosis. Impact statement Our review aimed to address maternal nutrition and its implications for the developmental origins of osteoporosis in offspring, that can novelly provide a theoretical basis for the early prevention of osteoporosis.

KEYWORDS:

Maternal; development; early life; nutrition; offspring; osteoporosis

PMID:
29792069
PMCID:
PMC6022911
DOI:
10.1177/1535370218779024
[Indexed for MEDLINE]
Free PMC Article

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