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Curr Opin Struct Biol. 2018 Aug;51:156-162. doi: 10.1016/j.sbi.2018.04.007. Epub 2018 May 20.

Computational design of antibodies.

Author information

1
Biolojic Design LTD, 9 Bialik Street, Givat Shmuel, Israel.
2
Biolojic Design LTD, 9 Bialik Street, Givat Shmuel, Israel; The Goodman Faculty of Life Sciences, Nanotechnology Building, Bar Ilan University, Ramat Gan 52900, Israel. Electronic address: yanay@ofranlab.org.

Abstract

Antibody design aims to create new antibodies with biological activity that can be used in therapy and research. Traditional methods for antibody discovery, such as animal immunization and large-scale library screening, generate antibodies that bind to the target of interest, but do not necessarily have the desired functional effect. Computational methods can be utilized as a means to guide the search for biologically relevant antibodies, focusing on specificity and affinity determinants to target a particular region of the antigen. Such an approach would allow for the design of epitope-specific antibodies that will have the desired effect on the function of the targeted protein.

PMID:
29791878
DOI:
10.1016/j.sbi.2018.04.007

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