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Mycopathologia. 2019 Feb;184(1):177-180. doi: 10.1007/s11046-018-0265-6. Epub 2018 May 22.

Asymptomatic Histoplasma Pylephlebitis in an Orthotopic Liver Transplant Recipient: A Case Report and Literature Review.

Author information

1
Division of Infectious Disease and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Bangkoknoi, Bangkok, 10700, Thailand. benefat@hotmail.com.
2
Division of Infectious Disease and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Bangkoknoi, Bangkok, 10700, Thailand.
3
Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
4
Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Abstract

Histoplasma capsulatum is one of the most common pathogenic dimorphic fungi in Thailand. Its usual clinical syndrome is progressive disseminated histoplasmosis, whereas isolated hepatic histoplasmosis is extremely rare. Here, we report the world's first reported case of hepatic histoplasmosis with pylephlebitis in a 45-year-old Thai male who underwent orthotopic liver transplantation due to hepatitis B cirrhosis. Histopathology of the recipient's liver showed infiltration of fungal organisms in portal vein and hepatic granulomas. Serum H. capsulatum antibody was positive, and molecular identification from the liver revealed the DNA of H. capsulatum.

KEYWORDS:

Histoplasma capsulatum; Histoplasmosis; Liver transplant; Pylephlebitis

PMID:
29789991
DOI:
10.1007/s11046-018-0265-6
[Indexed for MEDLINE]

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