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Arch Virol. 2018 Sep;163(9):2485-2489. doi: 10.1007/s00705-018-3874-y. Epub 2018 May 22.

New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017.

Author information

1
The Ohio State University, Wooster, Ohio, USA.
2
Northwest A & F University, Yangling, Shaanxi, China.
3
Ohio Department of Agriculture, 8995 East Main Street Building #6, Reynoldsburg, OH, 43068, USA.
4
Ohio Department of Agriculture, 8995 East Main Street Building #6, Reynoldsburg, OH, 43068, USA. yan.zhang@agri.ohio.gov.
5
Food Animal Health Research Program, Ohio Agricultural Research and Development Center, College of Food, Agricultural and Environmental Sciences; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Wooster, Ohio, USA. wang.655@osu.edu.

Abstract

Four types of porcine epidemic diarrhea virus (PEDV) variants with a large deletion in the spike protein were detected, together with the original US PEDV, from pig fecal and oral fluid samples collected during 2016-2017 in the US. Two of the variants are similar to those identified in Japan: one contains a 194-aa deletion, the same as PEDV variant TTR-2/JPN/2014, while the other contains a 204-aa deletion, the same as PEDV variant JKa-292/CS1de204. Two new S1 NTD-del PEDV variants were found: one contains a 201-aa deletion located at residues 30-230 and the other contains a 202-aa deletion located at residues 24-225 of the S protein. This is the first report on coinfection of S1 NTD-del PEDV variants and the original US PEDV strain in US pigs, indicating that PEDV continues to evolve in pigs and might be responsible for disease pattern changes.

PMID:
29789941
DOI:
10.1007/s00705-018-3874-y
[Indexed for MEDLINE]

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