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Nat Rev Immunol. 2018 Aug;18(8):485-497. doi: 10.1038/s41577-018-0020-8.

Regulatory mechanisms in T cell receptor signalling.

Author information

1
Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
2
Centre de Physiopathologie de Toulouse Purpan, Toulouse, France, and Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, and Université de Toulouse, Université Paul Sabatier, Toulouse, France.
3
Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. lovep@mail.nih.gov.

Abstract

The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular signals required for T cell development, repertoire selection and effector responses to foreign antigens. How TCR signals elicit such diverse cellular responses and outcomes remains a major question for investigation. Recent years have witnessed important advances in our understanding of the regulatory processes that control and modulate the TCR signalling response. Here, we review newly identified mechanisms for the regulation of TCR signalling and then discuss how the TCR signalling response is regulated to control two critical cellular processes - namely, positive selection and T cell homeostasis.

PMID:
29789755
DOI:
10.1038/s41577-018-0020-8
[Indexed for MEDLINE]

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