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Cell Res. 2018 Jun;28(6):616-624. doi: 10.1038/s41422-018-0040-8. Epub 2018 May 22.

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism.

Yang Y1,2,3, Hsu PJ4,5, Chen YS1,2, Yang YG6,7,8.

Author information

1
CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
2
University of Chinese Academy of Sciences, Beijing, 100049, China.
3
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
4
Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, 60637, USA.
5
Medical Scientist Training Program/Committee on Immunology, The University of Chicago, Chicago, IL, 60637, USA.
6
CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. ygyang@big.ac.cn.
7
University of Chinese Academy of Sciences, Beijing, 100049, China. ygyang@big.ac.cn.
8
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ygyang@big.ac.cn.

Abstract

N6-methyladenosine (m6A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m6A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m6A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.

PMID:
29789545
PMCID:
PMC5993786
DOI:
10.1038/s41422-018-0040-8
[Indexed for MEDLINE]
Free PMC Article

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