High-throughput discovery of functional disordered regions

Partially or fully intrinsically disordered proteins are widespread in eukaryotic proteomes and play important biological functions. With the recognition that well defined protein structure is not a fundamental requirement for function come novel challenges, such as assigning function to disordered regions. In their recent work, Babu and colleagues (Ravarani et al, 2018) took on this challenge by developing IDR‐Screen, a robust high‐throughput approach for identifying functions of disordered regions.