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Curr Drug Metab. 2018;19(10):830-838. doi: 10.2174/1389200219666180523095355.

Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives.

Author information

1
Department of Chemistry and Biochemistry, Faculty of Dental Medicine and Health, J. J. Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia.
2
Department of Pharmacology, Faculty of Medicine, J. J. Strossmayer University of Osijek, J. Huttlera 4, 31000 Osijek, Croatia.
3
Inspecto, LLC, Martina Divalta 193, 31000 Osijek, Croatia.
4
Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, United States.
5
Department of Pharmacology, Faculty Of Dental Medicine and Health, J. J. Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia.

Abstract

BACKGROUND:

Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases.

METHODS:

A structured search of bibliographic databases - Web of Science Core Collection, Scopus and Medline for peer-reviewed articles on models of DILI was performed. The reference lists of relevant studies was prepared and a citation search for the included studies was carried out. In addition, the characteristics of screened studies were described.

RESULTS:

One hundred and six articles about the existing knowledge of appropriate models to study DILI in vitro and in vivo with special focus on hepatic cell models, variations of 3D co-cultures, animal models, databases and predictive modeling and translational biomarkers developed to understand the mechanisms and pathophysiology of DILI are described.

CONCLUSION:

Besides descriptions of current applications of existing modeling systems, associated advantages and limitations of each modeling system and future directions for research development are discussed as well.

KEYWORDS:

Drug evaluation studies; drug-induced; evidence-based toxicology; liver injury; preclinical; side effects.

PMID:
29788883
PMCID:
PMC6174638
DOI:
10.2174/1389200219666180523095355
[Indexed for MEDLINE]
Free PMC Article

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