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Dev Cell. 2018 May 21;45(4):423-424. doi: 10.1016/j.devcel.2018.05.008.

Circuit Wiring: Neurite Speed Dating versus Stable Synaptic Matchmaking.

Author information

1
Department of Neuroscience, Columbia University Medical Center, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA.
2
Department of Neuroscience, Columbia University Medical Center, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA; Kavli Institute for Brain Sciences, Columbia University Medical Center, New York, NY 10027, USA. Electronic address: fp2304@columbia.edu.

Abstract

Understanding the mechanisms establishing the complex but precise pattern of connectivity characterizing neural circuits remains an immense challenge. In a recent issue of Neuron, Mao and colleagues (2018) provide new insights by showing that the activation kinetics of EphB2, a transmembrane receptor tyrosine kinase, control whether dendritic filopodia makes a synapse with candidate axons.

PMID:
29787706
DOI:
10.1016/j.devcel.2018.05.008
[Indexed for MEDLINE]

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