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Mar Drugs. 2018 May 22;16(5). pii: E174. doi: 10.3390/md16050174.

Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008.

Author information

1
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. bio_baoj@ujn.edu.cn.
2
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. zhai18363005528@163.com.
3
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. hkhhh.k@163.com.
4
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. yujinhai12@sina.com.
5
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. yuyingzhang2008@163.com.
6
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. bio_wangyy@ujn.edu.cn.
7
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. jiangchengshi-20@163.com.
8
College of Marine Sciences, South China Agricultural University, 483 Wushan Road, Guangzhou 510642, China. zhangxiaoyong@scau.edu.cn.
9
Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. zhangyun@scsio.ac.cn.
10
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. bio_zhangh@ujn.edu.cn.

Abstract

Eight new 4-hydroxy-2-pyridone alkaloids arthpyrones D⁻K (18), along with two known analogues apiosporamide (9) and arthpyrone B (10), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. The structures of the isolated compounds were elucidated on the basis of spectroscopic methods with that of 1 being established by chemical transformation and X-ray diffraction analysis. Compounds 1 and 2 bore an ester functionality linking the pyridone and decalin moieties first reported in this class of metabolites, while 3 and 4 incorporated a rare natural hexa- or tetrahydrobenzofuro[3,2-c]pyridin-3(2H)-one motif. Compounds 36 and 9 exhibited moderate to significant antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus with IC50 values ranging from 1.66⁻42.8 μM, while 9 displayed cytotoxicity against two human osteosarcoma cell lines (U2OS and MG63) with IC50 values of 19.3 and 11.7 μM, respectively.

KEYWORDS:

Arthrinium; antibacterial activity; cytotoxicity; pyridone alkaloid

PMID:
29786655
PMCID:
PMC5983305
DOI:
10.3390/md16050174
[Indexed for MEDLINE]
Free PMC Article

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