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Wiad Lek. 2018;71(2 pt 2):339-344.

Incidence and risk factors of spina bifida in children.

Author information

1
Pediatrics And Medical Genetics Department, Higher State Educational Establishment Of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine.
2
Medical Biology And Genetics Department, Higher State Educational Establishment Of Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine.
3
Medical Biology And Genetics Department, Higher State Educational Establishment Of Ukraine, "Bukovinian State Medical University", Chernivtsi, Ukraine.

Abstract

OBJECTIVE:

Introduction: The pathogenesis of spina bifida depends on time, region, race and ethnicity. It is found in 4.7 per 10.000 of live born children worldwide. The aim: The incidence in children of Northern Bukovina was analyzed. The spina bifida incidence for 2007-2016 in this region, as well as, compared to some countries according to EUROCAT data was studied.

PATIENTS AND METHODS:

Materials and methods: A retrospective study to analyze the risk factors for spina bifida was carried out. A case-control study was conducted using clinical records of 34 children with this pathology (16 boys and 18 girls) aged 0-18 years living in Northern Bukovina. 44 case records of healthy children (26 boys and 18 girls) were compared.

RESULTS:

Results: According to EUROCAT, the prevalence of spina bifida in the studied countries varied in the range of 0.13-0.50‰. The spina bifida incidence in Northern Bukovina (0.22 ‰) does not exceed the statistics for Ukraine (0.29 ‰) throughout the study period.

CONCLUSION:

Conclusions: This study provides a comprehension overview of a number of factors determining spina bifida risks: third pregnancy, miscarriage, high emotional stress during pregnancy, TORCH infection in pregnant, poor housing, maternal age, co-habiting, residence near contaminated lands, hard physical work preconceptionally, smoking habits, military service, etc. The most probable spina bifida preventive factors in children are: high school education of parents and using folic acid during the first trimester of pregnancy. Nevertheless, our data present new factual material, which requires further in-depth study, it is already clear that all the above indicators are associated with increased risk for spina bifida-complicated pregnancies.

KEYWORDS:

children ; incidence ; risk factors ; spina bifida

PMID:
29786583
[Indexed for MEDLINE]

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