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Sci Rep. 2018 May 21;8(1):7909. doi: 10.1038/s41598-018-26302-x.

Induction of prolonged natural lifespans in mice exposed to acoustic environmental enrichment.

Author information

1
Department of Functional Brain Research, National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Kodaira, Japan.
2
Department of Research and Development, Foundation for Advancement of International Science, Tsukuba, Japan.
3
Department of Functional Brain Research, National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Kodaira, Japan. honda@ncnp.go.jp.

Abstract

We investigated the effect of acoustic environmental enrichment (EE) on the lifespans and behaviours of mice to the end of their natural lifespan in different acoustic environments. Acoustic EE induced a significantly prolonged natural lifespan (nearly 17% longer) and was associated with increased voluntary movements. However, no correlation between lifespan and voluntary movements was detected, suggesting that increased voluntary movements are not a primary cause of lifespan prolongation. Analyses of individual differences in lifespan demonstrated that lifespan extension induced by acoustic EE could be related to changes in social relationships (e.g., reduction of social conflict) among individuals kept within a cage. Therefore, an acoustic component may be an important factor inducing the positive effects of EE.

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