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Nat Microbiol. 2018 Jun;3(6):687-697. doi: 10.1038/s41564-018-0162-2. Epub 2018 May 21.

Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria.

Author information

1
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK. thomasdan.otto@glasgow.ac.uk.
2
Centre of Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences University of Glasgow, Glasgow, UK. thomasdan.otto@glasgow.ac.uk.
3
Laboratoire MIVEGEC, UMR 5290-224 CNRS 5290-IRD224-UM, Montpellier, France.
4
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
5
Department of Infectious Disease Epidemiology, Imperial College London, London, UK.
6
International Livestock Research Institute, Nairobi, Kenya.
7
Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
8
Sodepal, Parc of la Lékédi, Bakoumba, Gabon.
9
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Abstract

Plasmodium falciparum, the most virulent agent of human malaria, shares a recent common ancestor with the gorilla parasite Plasmodium praefalciparum. Little is known about the other gorilla- and chimpanzee-infecting species in the same (Laverania) subgenus as P. falciparum, but none of them are capable of establishing repeated infection and transmission in humans. To elucidate underlying mechanisms and the evolutionary history of this subgenus, we have generated multiple genomes from all known Laverania species. The completeness of our dataset allows us to conclude that interspecific gene transfers, as well as convergent evolution, were important in the evolution of these species. Striking copy number and structural variations were observed within gene families and one, stevor, shows a host-specific sequence pattern. The complete genome sequence of the closest ancestor of P. falciparum enables us to estimate the timing of the beginning of speciation to be 40,000-60,000 years ago followed by a population bottleneck around 4,000-6,000 years ago. Our data allow us also to search in detail for the features of P. falciparum that made it the only member of the Laverania able to infect and spread in humans.

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PMID:
29784978
PMCID:
PMC5985962
DOI:
10.1038/s41564-018-0162-2
[Indexed for MEDLINE]
Free PMC Article

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