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Nutrients. 2018 May 18;10(5). pii: E639. doi: 10.3390/nu10050639.

Cobalamin and Folate Status among Breastfed Infants in Bhaktapur, Nepal.

Author information

1
Centre for Intervention Science in Maternal and Child Health, Centre for International Health, University of Bergen, P.O. Box 7800, 5020 Bergen, Norway. ram.chandyo@uib.no.
2
Department of Community Medicine, Kathmandu Medical College, P.O. Box 21266, Sinamangal, Kathmandu, Nepal. ram.chandyo@uib.no.
3
Department of Child Health, Institute of Medicine, P.O. Box 1524, Kathmandu, Nepal. manjeswori@gmail.com.
4
Regional Center for Child and Youth Mental Health and Child Welfare, West, Uni Research Health, P.O. Box 7810, 5020 Bergen, Norway. ingrid.Kvestad@uni.no.
5
Regional Center for Child and Youth Mental Health and Child Welfare, West, Uni Research Health, P.O. Box 7810, 5020 Bergen, Norway. mari.hysing@uni.no.
6
Department of Child Health, Institute of Medicine, P.O. Box 1524, Kathmandu, Nepal. drmerinashrestha@gmail.com.
7
Department of Child Health, Institute of Medicine, P.O. Box 1524, Kathmandu, Nepal. sumanra7@gmail.com.
8
Department of Clinical Science, University of Bergen, P.O. Box 7800, 5020 Bergen, Norway. arve.ulvik@uib.no.
9
Department of Clinical Science, University of Bergen, P.O. Box 7800, 5020 Bergen, Norway. per.ueland@ikb.uib.no.
10
Department of Child Health, Institute of Medicine, P.O. Box 1524, Kathmandu, Nepal. laxmanshree12@gmail.com.
11
Centre for Intervention Science in Maternal and Child Health, Centre for International Health, University of Bergen, P.O. Box 7800, 5020 Bergen, Norway. tor.strand@uib.no.
12
Innlandet Hospital Trust, P.O. Box 990, 2629 Lillehammer, Norway. tor.strand@uib.no.
13
Lillehammer University College, P.O. Box 952, 2604 Lillehammer, Norway. tor.strand@uib.no.

Abstract

Cobalamin and folate are crucial micronutrients during infancy and they are required for growth and cognitive development. Due to the monotonous and predominantly vegetarian-based complementary feeding and poor maternal micronutrient status, infants from low- and middle-income countries are susceptible to cobalamin deficiency. However, data on plasma cobalamin and folate and the functional markers methylmalonic acid and total homocysteine from breastfed infants in Nepal are still needed. We collected plasma samples from 316 6⁻11-month-old breastfed infants with a length-for-age of less than minus one z-score and analyzed blood for plasma folate, cobalamin, methylmalonic acid and total homocysteine concentrations. Cobalamin deficiency (plasma cobalamin 10 µmol/L) and methylmalonic acid (>0.28 µmol/L) indicating functional cobalamin deficiency were found among 53% and 75% of the infants, respectively. Based on a combined indicator of cobalamin status, 58% were found to have low cobalamin status. However, folate deficiency (.

KEYWORDS:

cobalamin; combined B12; folate; homocysteine and Nepal; infants; methylmalonic acid

PMID:
29783689
PMCID:
PMC5986518
DOI:
10.3390/nu10050639
[Indexed for MEDLINE]
Free PMC Article

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