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Int J Mol Sci. 2018 May 18;19(5). pii: E1509. doi: 10.3390/ijms19051509.

Clinical and Molecular Aspects of Vitiligo Treatments.

Author information

1
Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. dranha14@gmail.com.
2
Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. parsad@me.com.

Abstract

Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae. Vitiligo can be segmental or non-segmental depending upon the morphology of the clinical involvement. It can also be classified as progressing or stable based on the activity of the disease. Further, the extent of involvement can be limited (localized disease) or extensive (generalized disease). The treatment of vitiligo therefore depends on the clinical classification/characteristics of the disease and usually comprises of 2 strategies. The first involves arresting the progression of active disease (to provide stability) in order to limit the area involved by depigmentation. The second strategy aims at repigmentation of the depigmented area. It is also important to maintain the disease in a stable phase and to prevent relapse. Accordingly, a holistic treatment approach for vitiligo should be individualistic and should take care of all these considerations. In this review, we shall discuss the vitiligo treatments and their important clinical and molecular aspects.

KEYWORDS:

repigmenting treatments; stabilizing treatments; vitiligo

PMID:
29783663
PMCID:
PMC5983813
DOI:
10.3390/ijms19051509
[Indexed for MEDLINE]
Free PMC Article

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