Format

Send to

Choose Destination
Environ Pollut. 2018 Sep;240:817-830. doi: 10.1016/j.envpol.2018.04.130. Epub 2018 May 18.

Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.

Author information

1
Division of Digestive Diseases, Hepatology and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA. Electronic address: Ece_Mutlu@rush.edu.
2
Division of Digestive Diseases, Hepatology and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA. Electronic address: yagmurcomba@gmail.com.
3
Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: jared.cho@gmail.com.
4
Division of Digestive Diseases, Hepatology and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA. Electronic address: Phillip_A_Engen@rush.edu.
5
Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, IL, 60612, USA. Electronic address: cemalyazici@yahoo.com.
6
Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, 60611, USA. Electronic address: saulaxo@gmail.com.
7
Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: rhamanaka@medicine.bsd.uchicago.edu.
8
Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: recep@uchicago.edu.
9
Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: ameliton@medicine.bsd.uchicago.edu.
10
United States Environmental Protection Agency, Chapel Hill, NC, 27599, USA. Electronic address: Ghio.Andy@epa.gov.
11
Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, 60611, USA. Electronic address: s-buding@northwestern.edu.
12
Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, 60637, USA. Electronic address: gmutlu@medicine.bsd.uchicago.edu.

Abstract

Recent studies suggest an association between particulate matter (PM) air pollution and gastrointestinal (GI) disease. In addition to direct deposition, PM can be indirectly deposited in oropharynx via mucociliary clearance and upon swallowing of saliva and mucus. Within the GI tract, PM may alter the GI epithelium and gut microbiome. Our goal was to determine the effect of PM on gut microbiota in a murine model of PM exposure via inhalation. C57BL/6 mice were exposed via inhalation to either concentrated ambient particles or filtered air for 8-h per day, 5-days a week, for a total of 3-weeks. At exposure's end, GI tract tissues and feces were harvested, and gut microbiota was analyzed. Alpha-diversity was modestly altered with increased richness in PM-exposed mice compared to air-exposed mice in some parts of the GI tract. Most importantly, PM-induced alterations in the microbiota were very apparent in beta-diversity comparisons throughout the GI tract and appeared to increase from the proximal to distal parts. Changes in some genera suggest that distinct bacteria may have the capacity to bloom with PM exposure. Exposure to PM alters the microbiota throughout the GI tract which maybe a potential mechanism that explains PM induced inflammation in the GI tract.

KEYWORDS:

Air pollution; Feces; Gastrointestinal; Intestine; Microbiota

PMID:
29783199
PMCID:
PMC6400491
DOI:
10.1016/j.envpol.2018.04.130
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center