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J Microencapsul. 2018 May;35(3):301-311. doi: 10.1080/02652048.2018.1477845. Epub 2018 Jun 6.

Design and development of vitamin C-encapsulated proliposome with improved in-vitro and ex-vivo antioxidant efficacy.

Author information

1
a Department of Pharmaceutics, School of Pharmacy , Shiraz University of Medical Sciences , Shiraz , Iran.
2
b Department of Toxicology, School of Pharmacy , Shiraz University of Medical Sciences , Shiraz , Iran.
3
c Department of Quality Control, School of Pharmacy , Shiraz University of Medical Sciences , Shiraz , Iran.
4
d Pharmaceutical Sciences Research Center , Shiraz University of Medical Sciences , Shiraz , Iran.

Abstract

Vitamin C, as an antioxidant additive in pharmaceutical and food products, is susceptible to environmental conditions, and new design strategies are needed to enhance its stability. The aim of this study is to prepare vitamin C proliposome using film deposition on the carrier by applying different factors, and optimise the characteristics of the obtained powder using the design expert® software. The optimised formulation demonstrated acceptable flowability with 20% vitamin C loading. This formulation released about 90% vitamin C within 2 h and showed higher (1.7-fold) in-vitro antioxidant activity. Ex-vivo antioxidant activity was 1.9 and 1.6 times higher in brain and liver cells, respectively. A 27% reduction in malondialdehyde (MDA) level of liver cell was obtained comparing free vitamin C. Therefore, this study results suggest that the vitamin C-encapsulated proliposome powder might be an appropriate carrier for oral drug delivery of vitamin C with better antioxidant efficacy.

KEYWORDS:

Vitamin C; ex-vivo antioxidant activity; in-vitro antioxidant activity; proliposome

PMID:
29781344
DOI:
10.1080/02652048.2018.1477845
[Indexed for MEDLINE]

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