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Chem Sci. 2017 Mar 1;8(3):1705-1718. doi: 10.1039/c6sc05556g. Epub 2017 Jan 16.

Bimetallic catalysis for C-C and C-X coupling reactions.

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Department of Chemistry , University of Illinois at Chicago , 845 W. Taylor St. , Chicago , IL 60607 , USA . Email:


Bimetallic catalysis represents an alternative paradigm for coupling chemistry that complements the more traditional single-site catalysis approach. In this perspective, recent advances in bimetallic systems for catalytic C-C and C-X coupling reactions are reviewed. Behavior which complements that of established single-site catalysts is highlighted. Two major reaction classes are covered. First, generation of catalytic amounts of organometallic species of e.g. Cu, Au, or Ni capable of transmetallation to a Pd co-catalyst (or other traditional cross-coupling catalyst) has allowed important new C-C coupling technologies to emerge. Second, catalytic transformations involving binuclear bond-breaking and/or bond-forming steps, in some cases involving metal-metal bonds, represent a frontier area for C-C and C-X coupling processes.

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