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Trends Cell Biol. 2018 Aug;28(8):662-672. doi: 10.1016/j.tcb.2018.03.007. Epub 2018 May 17.

Nucleolar Function in Lifespan Regulation.

Author information

1
Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50931 Cologne, Germany; Present Address: Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
2
Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50674 Cologne, Germany. Electronic address: aantebi@age.mpg.de.

Abstract

The nucleolus is a prominent membraneless organelle residing within the nucleus. The nucleolus has been regarded as a housekeeping structure mainly known for its role in ribosomal RNA (rRNA) production and ribosome assembly. However, accumulating evidence has revealed its functions in numerous cellular processes that control organismal physiology, thereby taking the nucleolus much beyond its conventional role in ribosome biogenesis. Perturbations in nucleolar functions have been associated with severe diseases such as cancer and progeria. Recent studies have also uncovered the role of the nucleolus in development and aging. In this review we discuss major nucleolar functions that impact organismal aging.

KEYWORDS:

aging; lifespan; nucleolus; nutrient sensing pathways; ribosome biogenesis

PMID:
29779866
DOI:
10.1016/j.tcb.2018.03.007

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