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Heart Lung. 2018 Jul - Aug;47(4):425-428. doi: 10.1016/j.hrtlng.2018.04.008. Epub 2018 May 18.

Idiopathic systemic capillary leak syndrome presenting as septic shock: A case report.

Author information

1
Department of Intensive Care Medicine, The Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia; School of Public Health and Preventative Medicine, Monash University, Melbourne, VIC, Australia; Discipline of Acute Care Medicine, School of Medicine, The University of Adelaide, Adelaide, SA, Australia. Electronic address: eamon.raith@sa.gov.au.
2
School of Public Health and Preventative Medicine, Monash University, Melbourne, VIC, Australia; Department of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Commercial Road, Prahran, Melbourne, VIC 3181, Australia.
3
Department of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Commercial Road, Prahran, Melbourne, VIC 3181, Australia.
4
Department of Clinical Haematology, The Alfred Hospital, Commercial Road, Prahran, Melbourne, VIC 3181, Australia.
5
Department of Allergy, Immunology, Respiratory Medicine, The Alfred Hospital, Commercial Road, Prahran, Melbourne, VIC 3181, Australia.

Abstract

BACKGROUND:

Idiopathic capillary leak syndrome (Clarkson's Disease) is a rare angiopathy with a heterogenous phenotype that may present as distributive shock refractory to resuscitative management.

OBJECTIVE:

We report a case of idiopathic systemic capillary leak syndrome presenting as septic shock.

METHODS:

Structured case report and review of the literature.

RESULTS:

A 27-year old man admitted to our institution with coryzal symptoms rapidly deteriorated with presumed sepsis, leading to intensive care unit admission. Following further deterioration, Idiopathic systemic capillary leak syndrome was considered and intravenous immunoglobulin administered, resulting in rapid improvement in the patient's clinical status.

CONCLUSIONS:

Idiopathic systemic capillary leak syndrome is a rare and potentially life-threatening angiopathy that may present as, and should be considered in, refractory distributive shock. Administration of intravenous immunglobulin resulted in rapid recovery in this patient, and has been associated with positive outcomes in previous cases.

KEYWORDS:

Allergy and immunology; Capillary leak syndrome; Compartment syndromes; Critical care; Shock

PMID:
29779703
DOI:
10.1016/j.hrtlng.2018.04.008
[Indexed for MEDLINE]

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