Format

Send to

Choose Destination
Int J Pharm. 2018 Jul 30;546(1-2):194-214. doi: 10.1016/j.ijpharm.2018.05.037. Epub 2018 May 17.

Nano spray drying for encapsulation of pharmaceuticals.

Author information

1
NTB University of Applied Sciences of Technology Buchs, Institute for Energy Systems, Buchs, Switzerland. Electronic address: cordin.arpagaus@ntb.ch.
2
BÜCHI Labortechnik AG, Flawil, Switzerland.
3
Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
4
Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. Electronic address: smjafari@gau.ac.ir.

Abstract

Many pharmaceuticals such as pills, capsules, or tablets are prepared in a dried and powdered form. In this field, spray drying plays a critical role to convert liquid pharmaceutical formulations into powders. In addition, in many cases it is necessary to encapsulate bioactive drugs into wall materials to protect them against harsh process and environmental conditions, as well as to deliver the drug to the right place and at the correct time within the body. Thus, spray drying is a common process used for encapsulation of pharmaceuticals. In view of the rapid progress of nanoencapsulation techniques in pharmaceutics, nano spray drying is used to improve drug formulation and delivery. The nano spray dryer developed in the recent years provides ultrafine powders at nanoscale and high product yields. In this paper, after explaining the concept of nano spray drying and understanding the key elements of the equipment, the influence of the process parameters on the final powders properties, like particle size, morphology, encapsulation efficiency, drug loading and release, will be discussed. Then, numerous application examples are reviewed for nano spray drying and encapsulation of various drugs in the early stages of product development along with a brief overview of the obtained results and characterization techniques.

KEYWORDS:

Encapsulation; Nano spray drying; Nanoparticles; Pharmaceuticals; Powder properties

PMID:
29778825
DOI:
10.1016/j.ijpharm.2018.05.037
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center